IHC, Paraffin Sections, Frozen Sections, Western Blot
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Description
Epithelial Tumor Cell Marker: The Ber-EP4 EpCAM epitope is expressed by the vast majority of adenocarcinomas, neuroendocrine tumors such as small cell carcinomas of the lung. In non-neoplastic tissue sweat glands and hair bulbs express the Ber-EP4 epitope. Squamous cell carcinomas of the endoderm and the mesoderm usually express the Ber-EP4 epitope while those of the ectoderm are Ber-EP4-negative. The cells of the epidermis (squamous epithelium of the ectoderm) and mesothel do not express the Ber-EP4 epitope. The monoclonal antibody Ber-EP4 is highly suitable for the discrimination between basal cell carcinomas and squamous cell carcinomas of the epidermis. Ber-EP4 is also of great help in identifying remnants of basal cell carcinomas at the margin of biopsies or in biopsies with squeezing artefacts and also in recognizing basal cell carcinoma in statu nascendi. Ber-EP4 is also of value for another important differential diagnosis which is the distinction between mesotheliomas and adenocarcinomas.
Ber-EP4: New monoclonal antibody which distinguishes epithelia from mesothelia. Latza U, Niedobitek G, Schwarting R, Nekarda H, Stein H. J Clin Pathol 43:213-219, 1990. Ber-EP4 antibody as a discriminant in the differential diagnosis of malignant mesothelioma versus adenocarcinoma. Sheiban K, Shin SS, Kezirian J, Weiss LM.. Am J Surg Pathol 15:779-784, 1991. Ber-EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin. Beer TW, Shephard P, Theaker JM. Histopathology 37:218-223, 2000. Anti-Human Epithelial Antigen (Ber-EP4) helps define basal cell carcinoma masked by inflammation. Kist D, Perkins W, Christ S, Zachary CB. Dermatol Surg 23:1067-1070, 1997. The use of Ber-EP4 antigen in the differential diagnosis of basosquamous carcinoma from squamous and basal cell carcinoma. Karahan N, Baspinar S, Yildirim M, Barut I. Turk patoloji Dergisi 22:87-91, 2001