IHC, Paraffin Sections, Frozen Sections, Immunofluorescence, Western Blot, Immunoprecipitation
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Description
Fas ligand (FasL, CD 95L) is a type-II-membrane protein. Its receptor Fas (CD 95, Apo-1) is a cell-surface-type-I-membrane protein and a memberof the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family. FasL induces apoptosis when interacting with its receptor Fas. FasL may exist aseither membrane bound (45 kD) or soluble forms (26 kD). The soluble protein can be released from cells upon cleavage by metalloproteinases. Binding of FasL to Fas triggers apoptotic cell death. FasL is predominantly expressed in activated T-lymphocytes and natural killer (NK) cells. FasL expression is reported in various tissues as thymus, liver, ovary, lung, heart and kidney. The Fas/FasL system has been shown to play a role in a number of human diseases, for example AIDS, hepatitis or cancer.