IHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot, Immunocytochemistry, Immunoprecipitation
Reviews / Ratings
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Description
During cardiogenesis two major isoforms of myosin light chain 2 are co-expressed in a tightly regulated manner. MLC-2V is only present in the ventricle while MLC-2A is exclusively expressed in the atrium. Knock out studies revealed that the 2A isoform cannot substitute for the 2V variant in the ventricular chamber. Recently it has been demonstrated that embryonic and adult stem cells can be differentiated into cardiomyocytes which may generate suitable replacements for damaged heart tissue in the future. These monoclonal antibodies (#SySy310111 & #SySY311011) are useful tools to distinguish between ventricle and atrium specific cardiomyocytes.
Immunogen
Recombinant protein of human myosin light chain 2V.
p38 MAPK-dependent small HSP27 and αB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest. Clements RT, Feng J, Cordeiro B, Bianchi C & Sellke FW. American Journal of Physiology. Heart and Circulatory Physiology 300: H1669-77, 2011. / Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction. Behfar A, Yamada S, Crespo-Diaz R, Nesbitt JJ, Rowe LA, Perez-Terzic C, Gaussin V, Homsy C, Bartunek J & Terzic A. Journal of the American College of Cardiology 56: 721-34. clone 330G5, 2010. / Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction. van Laake LW, Passier R, Monshouwer-Kloots J, Verkleij AJ, Lips DJ, Freund C, den Ouden K, Ward-van Oostwaard D, Korving J, Tertoolen LG, van Echteld CJ, Doevendans PA & Mummery CL. Stem Cell Research 1: 9-24, 2007