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Description
CAL2 labels the megakaryocytes in myeloproliferative neoplasms (essential thrombocythaemia (ET) and primary myelofibrosis (PMF)) with CALR mutation and enables to distinguish ET and PMF with CALR mutation from polycythemia vera (PV), from CALR mutation negative ET and PMF and from reactive bone marrow.
Immunogen
C-neoterminus of mutated CALR
Other Names
Sicca Syndrome Antigen A, Endoplasmic Reticulum Resident Protein 60, Calregulin, ERp60, CRP55, HACBP, Grp60, Epididymis Secretory Sperm Binding Protein Li 99n, Autoantigen Ro, HEL-S-99n, CC1qR, CRTC, SSA, CRT, RO
A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies.Stein H, Bob R, Durkop H, Erck C, Kampfe D, Kvasnicka HM, Martens H, Roth A, Streubel A., Leukemia. 2015 Jul 23. doi: 10.1038/leu.2015.192.