IHC, Paraffin Sections (FFPE), Frozen Sections, Immunoprecipitation, Western Blot
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Description
N-ethylamide sensitive fusion protein NSF functions together with SNAPs (soluble NSF attachment proteins) and SNAREs (SNAP receptors) in vesicular transport. NSF is an ATPase that dissociates SNARE complexes, such as the core complex composed of synaptobrevin/VAMP, syntaxin 1 and SNAP 25 under ATP hydrolysis.
Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling. Ohno Y, Ishihara S, Terada R, Kikuta M, Sofue N, Kawai Y, Serikawa T & Sasa M. Biochemical and Biophysical Research Communications 390: 415-20, 2009. / A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners. Khanna R, Zougman A & Stanley EF. Journal of Biochemistry & Molecular Biology 40: 302-14, 2007. / The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. Tian JH, Wu ZX, Unzicker M, Lu L, Cai Q, Li C, Schirra C, Matti U, Stevens D, Deng C, Rettig J & Sheng ZH. Journal of Neuroscience: 25: 10546-55, 2005.