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Description
Anti-PD-1 antibody clone NAT105 is suitable for the immunohistological detection of Follicular helper T cells (TFH), Tumor-infitrating T cells (TILs) whose anti-tumor activity is inhibited by PD-1, Lymphomas derived from TFH cells including Angioimmunoblastic T-cell lymphoma, Primary cutaneous CD4-positive small/medium T-cell lymphoma, Follicular variant of peripheral T-cell lymphoma NOS. Moreover, monoclonal antibodies to PD1 and PDL1 are currently being investigated in clinical trials for their potential to inhibit this pathway with the effect of elevated tumor immunity - Background: PD-1 plays a key role in peripheral tolerance and autoimmune disease. Several tumors express ligand for PD1 (PDL1). On binding activated T cells in the tumor microenvironment, PD-1 inactivates antigen specific T cells that would other-wise attack tumor cells.
Immunogen
TY cells (human T/NK Leukemia)
Other Names
Programmed Cell Death 1, PD-1, CD279, PDCD1, SLEB2
Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma.Roncador, G., Verdes-Montenegro, J.F.G., Tedoldi, S., Paterson, J.C., Klapper, W., Ballabio, E., Maestre, L., Pileri, S., Hansmann, M.L., Piris, M.A., Mason, D.Y., Marafioti, T. Haematologica. 2007 Aug;92(8):1059-66.