Purity > 90% as determined by SDS-PAGE. MW: 46.3kDa. Full Length: 1-176aa. N-terminal GST-tagged. Homo sapiens (Human). The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Down-regulator of transcription 1; Negative cofactor 2-beta