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Description
Carcinoma associated antigen MAM-6 also known as a milkfat globule membrane antigen is a mucus glycoprotein of;400 kD that is located mainly in the glycocalyx of most glandular epithelial cells. It is also located in the cytoplasm and on the membrane of most carcinoma cells and some other tumor cells. Antibody 115D8 recognizes epitope "a" of MAM-6 and reacts very strongly with a majority of carcinomas (99.2%) and adenomas (61.4%). It occasionally shows a very weak cross reactivity with sarcomas and leukemias. It does not react with normal intestine or colorectal adenomas, but reacts with colorectal carcinomas.