| Edit |   |
|---|
| Antigenic Specificity | APC |
|---|
| Clone | Ali 12-28 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | peroxidase (HRP) conjugate |
|---|
| Size | 50ul |
|---|
| Concentration | 1mg/ml |
|---|
| Applications | ELISA, IHC-Fr, IP, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Mouse anti APC [Ali 12-28]: Horseradish peroxidase (HRP). This antibody recognises adenomatous polyposis coli (APC), a 310kDa protein that functions as a tumour suppressor. APC tumour suppressor gene is mutated in the inherited disease familial adenomatous polyposis (FAP) and in over 80% of colorectal cancers. The antibody Ali 12-28 recognises a region corresponding to nucleotides 135 and 422 of the APC (exons 2-3) in the N-terminus. It detects both normal and mutant-truncated forms of the APC and may be used for the detection of APC expression and APC mutations. Species reactivity: Human. Does not cross react with mouse |
|---|
| Immunogen | N-terminal APC-MBP fusion protein |
|---|
| Other Names | adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; Adenomatous polyposis coli protein; APC; BTPS2; Deleted in polyposis 2.5; DP2; DP2.5; DP3; GS; Protein APC |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | IQ615HRP |
|---|
| Price | |
|---|
| Order / More Info | APC Antibody from IMMUQUEST LTD. |
|---|
| Product Specific References | Efstathiou JA, et al. Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. Proc Natl Acad Sci.1998.95(6):3122-7. PMID:9501226 http://www.ncbi.nlm.nih.gov/pubmed/9501226 |
|---|