Salmonella enterica is a Gram-negative intracellular bacterial pathogen of animals. Salmonella is a major cause of enteritis across the world and is also the cause of typhoid, a frequently fatal disease prevalent in developing nations. Salmonella induced enteritis involves penetration of the intestinal epithelium and, through interactions with epithelial and immune cells, it induces inflammation in the intestine resulting in diarrhea. The principle factors allowing Salmonella to penetrate the intestinal epithelium and replicate within phagocytes of the host are `effectors', proteins that are injected into infected host cells by type III secretion systems (T3SSs), SeNleB is one of this pathogenic effectors.