Purity >98%. A-196 is a selective inhibitor of SUV420H1 and SUV420H2 (IC50 s = 25 and 144 nM, respectively) that is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. A-196 has been shown to inhibit the di- and tri-methylation of lysine 20 of histone H4 (H4K20me) in multiple cell lines with IC50 values less than 1 μM. See the Structural Genomics Consortium (SGC) website for more information.