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Description
Bispecific monoclonal antibodies are recombinant antibodies composed of fragments from two different monoclonal antibodies and therefore can bind to two different antigens. The bispecific nature of these antibodies have been classically exploited to link cancer antigen bearing cells to cytotoxic cells such as those expressing CD3, for the rapid removal of those cancerous cells. Addition of the bispecific CD3.4 monoclonal antibody to long term peripheral blood co-cultures results in the potent elimination of CD4+ T cells. The remaining cells are highly activated and serve as a reliable source of purified activated cells of interest.