If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
This antibody displays binary epitope reactivity directed to gp120 residues 301-311 and residues 421-433. IgG neutralizes subtype C HIV strain 97ZA009 (primary isolate) with an IC50 value of 8.2 ?g/mL using pooled human peripheral bloord mononuclear cells (PBMC). Endotoxin concentration in stock IgG solution is 0.14 EU/mL. The endotoxin concentration will be 0.006 EU/mL at final concentration in the neutralization assay equivalent to the IC50 (8.2 ?g/mL); Binds electrophilic 416-433 peptide detectably at 50 ?g/mL.1. This antibody preparation does not neutralize pseudovirion infection of the TZm-bl cell line. It neutralizes infection of PHA-activated human PBMCs by genetically diverse primary strains [belonging to subtypes A, B and C].