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Description
IRS1(Tyr896) Polyclonal Antibody, Alexa Fluor? 680 Conjugated. ? Target Background: Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wil
Immunogen
KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Tyr896 [GE(p-Y)VN]