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Description
Rabbit polyclonal antibody to BCR. The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
Immunogen
Recombinant protein of human BCR
Other Names
ALL, BCR1, CML, D22S11, D22S662, PHL, Breakpoint cluster region protein, Renal carcinoma antigen NY-REN-26