IHC, Paraffin Sections, Frozen Sections, Immunofluorescence, Western Blot, Immunoprecipitation, ELISA
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Description
The p53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. Many mutations of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 immunostaining is of use in demonstrating accumulation of p53 protein, which occurs in a high frequency in a wide variety of transformed cells. Positive nuclear staining with this antibody has been shown to be a negative prognostic factor in Breast carcinoma, Lung carcinoma, Colorectal, and Urothelial carcinoma. p53 positivity has also been used to differentiate Uterine serous carcinoma from endometrioid carcinoma as well as to detect Intratubular germ cell neoplasia.