SNAP 25 (Epitope: Close to the N-terminus of the protein (aa 1 - 20))
Clone
71.2
Host Species
Mouse
Reactive Species
human, rat, mouse, mammals
Isotype
IgG1
Format
purified
Size
50 μg
Concentration
n/a
Applications
IHC, Paraffin Sections (FFPE), Frozen Sections, Immunocytochemistry, Western Blot, Immunoprecipitation
Reviews / Ratings
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Description
No signal in zebrafish. SNAP 25 (5 (synaptosome-associated protein of 25 kDa) is part of the exocytotic fusion complex (v-SNARE) of neurons where it assembles with syntaxin 1 and synaptobrevin. It is abundantly localized on the neuronal plasmalemma and on recycling vesicles including synaptic vesicles. It is also expressed in neuroendocrine cells. SNAP 25 is a highly conserved protein anchored to the cytosolic face of membranes and is the target of Botulinum neurotoxin A and E.
Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease. Smith R, Klein P, Koc-Schmitz Y, Waldvogel HJ, Faull RL, Brundin P, Plomann M & Li JY. Journal of Neurochemistry 103: 115-23, 2007. / Palisade endings in extraocular eye muscles revealed by SNAP-25 immunoreactivity. Eberhorn AC, Horn AK, Eberhorn N, Fischer P, Boergen KP & Buttner-Ennever JA. Journal of Anatomy 206: 307-15, 2005 / The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina. von Kriegstein K& Schmitz F. Cell Tissue Research 311: 159-73, 2003.