human, rat, mouse, mammals; birds, zebrafish; lower vertebrates with lower reactivity.
Isotype
IgG1
Format
ascites
Size
100 μl
Concentration
n/a
Applications
IHC, Paraffin Sections (FFPE), Frozen Sections, Immunocytochemistry, Western Blot, Immunoprecipitation
Reviews / Ratings
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Description
Synapsin 1 is probably the most specific marker of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells.
Immunogen
Electrophoretically purified rat synapsin 1.
Other Names
SYN1, SYNI, SYN1a, SYN1b, Syn-1, si:dkey-90n12.3, SYN I, Synapsin-1
Tissue multicolor STED nanoscopy of presynaptic proteins in the calyx of held. Kempf C, Staudt T, Bingen P, Horstmann H, Engelhardt J, Hell SW & Kuner T. PLos One 8(4): e62893, 2013. / Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse. Varoqueaux F, Sons MS, Plomp JJ & Brose N. Molecular and Cellular Biology: 25: 5973-84, 2005. / Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Beglopoulos V, Montag-Sallaz M, Rohlmann A, Piechotta K, Ahmad M, Montag D & Missler M. Molecular and Cellular Biology 25: 7278-88, 2005 / Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. Talbot K, Eidem WL, Tinsley CL, Benson MA, Thompson EW, Smith RJ, Hahn CG, Siegel SJ, Trojanowski JQ, Gur RE, Blake DJ & Arnold SE. Journal of Clinical Investigation 113: 1353-63, 2004 /Changes in retinalsSynapticpProteins in the transgenic model expressing a mutant HRG4 (UNC119). Kubota S, Kobayashi A, Mori N, Higashide T, McLaren MJ & Inana G. Investigative Ophthalmology and Visual Science 43: 308-13, 2002.