Synaptobrevin 2 / VAMP 2 (no cross-reactivity to VAMP 1 and VAMP 3)
Clone
69.1
Host Species
Mouse
Reactive Species
human, rat, mouse, hamster, cow
Isotype
IgG1
Format
purified
Size
50 μg
Concentration
n/a
Applications
IHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot, ELISA
Reviews / Ratings
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Description
No signal in chicken, no signal in zebrafish. Synaptobrevin/VAMP is an essential component of the exocytotic fusion machine, related to a larger protein family referred to as v-SNAREs. It is the sole target for tetanus and several of the botulinal neurotoxins. Synaptobrevins/VAMPs represents a family of integral membrane proteins. Two isoforms were identified in the mammalian CNS, synaptobrevin 1 (VAMP 1) and synaptobrevin 2 (VAMP 2) that differ in their distribution within different brain regions.
Immunogen
Synthetic peptide SATAATVPPAAPAGEG (aa 2 - 17 in rat synaptobrevin 2) coupled to key-hole limpet hemocyanin via an added N-terminal cysteine residue.
Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. Johnson PT, Brown MN, Pulliam BC, Anderson DH & Johnson LV. Investigative Ophtalmology and Visual Science 46: 4788-9, 2005. / Differential distribution of vesicle associated membrane protein isoforms in the mouse retina. Sherry DM, Wang MM & Frishman LJ. Molecular Vision 9: 673-88, 2003 / Brain synaptic junctional proteins at the acrosome of rat testicular germ cells. Redecker P, Kreutz MR, Bockmann J, Gundelfinger ED & Boeckers TM. Journal of Histochemistry and Cytochemistry 51: 809-19, 2003 / Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. von Kriegstein K, Schmitz F, Link E & Sudhof T. European Journal of Neuroscience 11: 1335-48, 1999.