IHC, Paraffin Sections (FFPE), Western Blot, Immunoprecipitation, Immunocytochemistry, ELISA
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Description
Useful Marker for normal neuroendocrine cells and neuroendocrine tumors: Synaptophysin is a most reliable and specific marker molecule for normal and neoplastic neuroendocrine cells in the nerveous system. Synaptophysin 1 is a membrane glycoprotein of synaptic vesicles that is ubiquitously expressed in all neurons and in many endocrine cells. It forms a complex with dynamin at high Ca2+ concentration suggesting an involvement in synaptic vesicle endocytosis.
Immunogen
Electrophoretically purified synaptophysin. Epitope: Reacts with cytoplasmic tail of synaptophysin 1, no cross-reactivity to other synaptophysins.
Other Names
major synaptic vesicle protein p38, MRXSYP, Syn, p38, AI848995, A230093K24Rik, Syp1, mrxsyp, syp, xsypi, syp-B, xsypii, MGC86267
The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina. von Kriegstein K & Schmitz F. Cell Tissue Research 311: 159-73, 2003. / Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. von Kriegstein K, Schmitz F, Link E & Sudhof T. European Journal of Neuroscience 11: 1335-48, 1999