15(S)-HETE is a major arachidonic acid metabolite produced by the 15-LO pathway. It has been characterized as a potent inhibitor of 5-LO.{6483,570} The mechanism by which 15(S)-HETE acts as a leukotriene inhibitor is not clear. In studies with P-18 mast/basophil cells, it was shown that specific 15-HETE receptors, rather than esterification, appeared to be involved in signal transduction.{1476} 15(S)-HETE-biotin can be used to detect 15(S)-HETE binding proteins and/or receptors.{6482}