An SSRI, displaying a marked preference for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM); effective in animal models of depressive-like behavior; reverses depressive-like behavior induced by unpredictable chronic mild stress in wild-type mice and cyclin D2 knockout mice, which lack adult neurogenesis