The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.
Size
Various Sizes
Concentration
n/a
Applications
Cell Culture
Other Names
Interleukin-36 beta;FIL1 eta;Interleukin-1 eta;IL-1 eta;Interleukin-1 family member 8;IL-1F8;Interleukin-1 homolog 2;IL-1H2;IL36B;IL1F8, IL1H2; IL-1F8?, IL-1H2, IL-1 eta