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Description
CD56 is an isoform of the Neural Cell Adhesion Molecule (NCAM). CD56 is an adhesion molecule involved in intercellular homophilic adhesion and plays a role in outgrowth of neurites and the development of the nervous system. Furthermore CD56 is a marker for natural killer cells and found in various tumors. Several isoforms of NCAM have been identified: two transmembrane isoforms of 140 and 180 kD, a GPI-linked isoform of 120 kD which lacks a transmembrane domain and a fourth variant which is leading to the expression of a soluble form (sNCAM). Antibody NKI-nbl-1 recognizes the transmembrane glycoprotein of 140 and 180 kD.