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Description
Mouse anti Fbxw7/Cdc4 [FBOX 3a9/1]: Horseradish peroxidase (HRP). This antibody recognises F-box/WD repeat-containing protein 7 (Fbxw7), which is also known as cdc4 and SEL-10. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 negatively regulates several key oncoproteins and is a tumour suppressor that is mutated in a wide spectrum of human cancers.
Immunogen
Synthetic peptide of human sequence
Other Names
AGO; Archipelago homolog; archipelago, Drosophila, homolog of; CDC4; DKFZp686F23254; F-box and WD repeat domain containing 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; F-box/WD repeat-containing protein 7; FBW6; FBW7; FBX30; FBXO30; FBXW6; FBXW7; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL-10; SEL10