CD153, soluble, Recombinant, Human (CD30 Ligand, CD30L, TNFSF 8)
Description
Purity ~95% (SDS-PAGE). Endotoxin: <0.1EU/ug. The CD30 ligand (CD30L, CD153) is a member of the tumor necrosis factor (TNF) family. CD30L is a type II, transmembrane protein expressed on T and B cells, monocytes/macrophages, neutrophils, megakaryocytes, erythroid precursors and eosinophils. After interaction with its receptor CD30, CD30L may induce TNF receptor-associated factor 1 (TRAF1), TRAF2, 3 and 5 recruitment. CD30-CD30L have been reported to be involved in costimulation of T cell proliferation, induction of HIV expression, negative selection and apoptosis as well as in diabetes and several allergic, viral and autoimmune diseases. Source: Produced in HEK 293 cells. The extracellular domain of recombinant human CD30L (CD153) (aa63-234) is fused at the N-terminus to a linker peptide (11aa) and a FLAG-tag. Molecular Weight: ~35kD (SDS-PAGE, under reducing conditions). Reconstitution: Reconstitute with 100ul sterile ddH2O. Further dilutions should be made with medium containing 5% f