Recombinant Human Sodium/calcium exchanger 1 (SLC8A1), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 27.4kDa. Partial: 396-627aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Mediates the exchange of one Ca2+ ion against three to four Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Na (+)/Ca (2+)-exchange protein 1; Solute carrier family 8 member 1