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Description
Monoclonal antibody h6 recognizes human ?-hCG. hCG is a well defined oncofetal protein dimer of 36.7 kD associated with pregnancy and some cancers. The ?-chain (14.5 kD) is common to three other glycoprotein hormones (TSH, FSH, LH) whereas the ?-chain is markedly different. The ?-chain of hCG and LH (lutrophin) have sequence homology in the first 112 amino acids and differ at the C-terminal end consisting of 24 amino acids. Raised serum levels for hCG are found in teratogenic carcinomas and trophoblastic tumors and occasionally in gastrointestinal-, urogenital-, bronchial-, and mammary carcinomas and in lymphomas. Application: IHC (f) Chorionic Gonadotropin-? (109-119) amide (human) is a Bachem catalog product (H-1378).