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Description
UniProt: Q96LB1. MRGPRX2 or cortistatin receptor is a 330 amino acid protein that belongs to the G-protein coupled receptor 1 family. Mas-related G-protein coupled receptors (Mrgprs) represent a large family of orphan receptors specifically expressed in small-diameter nociceptive primary sensory neurons. Physiological functions include mediation of itch or regulation of persistent pathological pain. Cortistatin-14, which is involved in sleep regulation, locomotor activity, and cortical function, seems to be a high potency ligand at this receptor. Also, the multifunctional antibacterial protein LL-37 (H-7298) has been shown to activate cells presumably through MRGPRX2. Application: IHC (p)
Immunogen
n/a
Other Names
Mas-Related G-Protein Coupled Receptor Member X2, Cortistatin Receptor