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Description
BTF Antibody. The initiation of gene transcription involves the ordered assembly of a multiprotein complex on proximal promoter elements such as the TATA box. In addition to RNA polymerase II, the transcription factors class II (TFII) family of proteins are required for initiation of transcription, as the first step in the formation of this initiation complex is the stable binding of TFIID to the TATA box. An additional TFII related protein, BTF3, does not directly associate with the proximal promoter, but rather forms a stable complex with RNA pol II and facilitates RNA pol II assembling into the complex. The BTF3 gene is ubiquitously expressed and encodes for two protein isoforms, BTF3a and BTF3b, which are produced from alternative splic