A potent JAK2 inhibitor (Ki = 0.45 nM in vitro) that decrease STAT3/5 phosphorylation and inhibits cell proliferation (GI50 = 33 nM) in a JAK2 V617F mutated cell line; induces apoptosis in human T cell lymophotropic virus type 1-infected (IC50 = ~1 μM), downregulating phosphorylated forms of JAK2 and Bcl-2 family proteins
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
Janus-associated kinase JAK2 myeloproliferative disease V617F mutation leukemia lymphoma ATL cancer signal transduction apoptosis Bcl-2 inhibit JAK 2 cytoplasmic cytoplasm tyrosine signaling cytokine growth factor receptor mutation valine phenylalanine aggressive adult T cell leukemia lymphoma in vitro STAT3/5 phosphorylation proliferation SET-2 two human megakaryoblastic line induce death lymphotropic virus type 1-infected downregulation downregulate down regulate family protein Bcl2 AZ960 SET2 AZ 960