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Description
Purified anti-β-Tubulin. Eukaryotic microtubules are tubular polymers of tubulin that are a major component of the cytoskeleton. They play an essential role in diverse cellular functions, including migration, mitosis, and trafficking, and are also critical for normal development. β- and α-tubulins comprise the two core protein families that heterodimerize and assemble into each microtubule filament. There are multiple β- and α-tubulins isotypes, with each showing unique tumoral and tissue-specific distribution. TUBB4A is a β–tubulin primarily expressed in nervous tissue and moderate expression in testis. Mutations in TUBB4A cause hypermyelinating leukodystrophy-6 and autosomal dominant torsion dystonia -4.
Immunogen
Full length protein expressed in HEK293T cells transfected with human TUBB4 expression vector.