Recombinant Rat Inducible T-cell costimulator (Icos), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 18.1kDa. Extracellular Domain: 21-145aa. N-terminal 6xHis-tagged. Rattus norvegicus (Rat). Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).