Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two members of the herpes virus family, Herpesviridae, that infect humans. Both HSV-1 (which produces cold sores) and HSV-2 (which produces genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus. Alternative Names: HSV gD 1 protein, HSV gD-1 protein, HSV gD-1, HSV1 gD, HSV gD 1, Herpes Simplex Virus 1 glycoprotein D protein