A bicyclic sesquiterpene; a metabolite of β-caryophyllene that has been found in C. sativa; does not bind to the cannabinoid (CB) receptor CB2 (Ki = >20 μM); induces calcium currents in HL-60 cells expressing CB2 receptors but also does so in CB2-deficient cells; cytotoxic to HepG2, AGS, HeLa, SNU-1 and SNU-16 cells (IC50s = 3.95, 12.6, 13.55, 16.79, and 27.39 μM, respectively); the volatile component of C. sativa sensed by narcotic detection dogs