Purity ~90% (SDS-PAGE). MPZL1 is a cell surface receptor, which is involved in signal transduction processes. This protein recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. It is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. Source: Recombinant protein corresponding to aa38-162 from human MPZL1, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~16.1kD (148aa) AA
Size
50ug, 250ug
Concentration
n/a
Applications
n/a
Other Names
MPZL1, Recombinant, Human, aa38-162, His-Tag(Myelin protein zero-like protein 1 Isoform b, MPZL1b, PZR, PZR1b, PZRa, PZRb)