A reversible, orally bioavailable dual inhibitor of IGF-1R and InsR tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively); inhibits cell proliferation or induces apoptosis in a variety of cancer cells in vitro; inhibits the growth of tumor xenografts in mice
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
1319719-58-8 1446701-47-8 BMS754807 BMS-754807 inhibitor IGF-1R InsR tyrosine kinase apoptosis biochemical cancer cell cycle protein receptor biochemistry signal transduction insulin insulin-like growth factor 1