An erastin analog that has antitumor activity; inhibits the HIF-1 signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay); inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells at 1 μM; inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells (IC50s = <100 nM); inhibits tumor growth in PANC-1 and HT-1080 xenograft models at 50 mg/kg and induces tumor regression at 100 mg/kg