Protein phosphorylation is a common post-translational modification of proteins in eukaryotes and plays critical roles in numerous cellular processes including cell differentiation, proliferation, migration, metabolism, and neuronal communication. Phosphorylation regulates protein functions by changing protein's conformation, which is essential the catalytic activity of protein. The process is usually reversible. In addition, phosphorylated proteins can be recogniezd and bound to phosphomotifs of neighbour proteins which have conserved domains.