A natural coumestan that inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 μM; also inhibits hepatitis C virus NS5B polymerase in vitro (IC50 = 36 μM), STAT1 dephosphorylation (50 μM), and EZH2-EED interactions (Kd = 2.8 μM)