Recombinant Human Gamma-secretase subunit APH-1A (APH1a), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 42.9kDa. Partial: 1-247aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.