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Description
The antibody detects a 34 kDa band corresponding to Cdk1 on SDS-PAGE immunoblots of human SYF and HeLa cells, and this band is removed after alkaline phosphatase treatment. The antibody may also detect Tyr-15 phosphorylation in Cdk2, Cdk3, Cdk5, and Cdk6.
Immunogen
Clone M231 was generated from a phospho-Cdk1 (Tyr-15) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding Tyr-15 in human Cdk1. This sequence is conserved in rat and mouse Cdk1, and is highly conserved in other Cdks, including Cdk2, Cdk3, Cdk5, and Cdk6.