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Description
The RGM domain family member B (RGMB) is a glycosylphosphatidylinositol (GPI)-anchored member of the Repulsive Guidance Molecule family which plays a role in patterning of the developing nervous system. There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling. Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis. This antibody is recommended for applications under non-denaturing conditions.