A potent and selective inhibitor of Vps34 (IC50 = 25 nM in vitro); dose-dependently inhibits generation of PtdIns-(3)-p, which is essential to the formation and trafficking of endsomes and autophagosomes, without affecting the ability of class I PI3K to regulate Akt; induces a rapid and pronounced loss of phosphorylation on serum- and glucocorticoid-regulated kinase 3,
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
Vacuolar Protein Sorting 34 Inhibitor 1|Vps34 Inhibitor 1