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Description
Mouse anti HIF-1 alpha [ESEE122]: Fluorescein. This antibody recognises hypoxia-inducible factor 1 alpha (HIF-1 alpha). Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours.
Immunogen
GST-human HIF-1A amino acids 329-530 fusion protein
Other Names
ARNT interacting protein; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; Class E basic helix-loop-helix protein 78; HIF-1-alpha; HIF-1alpha; HIF1; HIF1-alpha; HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Hypoxia-inducible factor 1-alpha; Member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8
Talks KL, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol.2000.157(2):411-21. PMID:10934146 http://www.ncbi.nlm.nih.gov/pubmed/10934146