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Description
Mouse Anti-Lamin B1 + B2 antibody [X223] - Nuclear Envelope Marker. Reacts with COS cells in immunocytochemistry and is said to detect the karyoskeleton. Other cell/tissue types have not been tested. In mouse the antibody detects Lamin B2 only.
Immunogen
Full length native lamin B2 protein (purified) (Xenopus laevis) (XLKE-A6 cells)
The nuclear lamins. A multigene family of proteins in evolution and differentiation. Krohne G ( Exp Cell Res.,Jan 1986) PUBMED Arruda DC et al. AY-Actin-binding complementarity-determining region 2 of variable heavy chain from monoclonal antibody C7 induces apoptosis in several human tumor cells and is protective against metastatic melanoma. J Biol Chem 287:14912-22 (2012). ICC/IF ; Human PUBMED Machiels BM et al. Nuclear lamin expression in normal testis and testicular germ cell tumours of adolescents and adults. J Pathol 182:197-204 (1997) PUBMED Ulbert S et al. The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology. FEBS Lett. 2006 Nov 27;580(27):6435-41. Epub 2006 Nov 3. ICC/IF, WB (Human) PMID: 17097643