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Description
Purified anti-CD141 (Thrombomodulin). CD141 is a 75 kD, single chain, type I membrane glycoprotein also known as thrombomodulin, TM, THRM, THBD, and fetomodulin. CD141 is an important cofactor in the protein C anticoagulant system. After binding to its ligand thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. CD141 is expressed on macrophages, monocytes, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. Besides anti-coagulation function, CD141 is also involved in embryonic and atherosclerotic plaque development. ?CD141 is an endothelial cell surface glycoprotein involved in the regulation of coagulation. Via a direct interaction with thrombin, thrombomodulin causes down-regulation of multiple pro-coagulation pathways in order to preserve the anticoagulant properties of the endothelial cell surface.