Recombinant Mouse Homeobox protein Nkx-2.2 (Nkx2-2)
Description
Purity > 90% as determined by SDS-PAGE. MW: 46.1kDa. Full Length: 1-273aa. N-terminal 6xHis-SUMO-tagged. Mus musculus (Mouse). Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter.