An ectoparasiticide and antipruritic agent; blocks mouse TRPV4 channel expressed in HEK293 cells in a calcium-dependent manner (IC50s = 223.5 and 15.5 μM in buffer containing 0 and 2 mM calcium, respectively); inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A; topical application inhibits scratching behavior in mice induced by histamine, serotonin, and the PAR2 agonist SLIGRL-NH2 (0.025 g of a 10% ointment)