Protein Phosphatase 2, Catalytic Subunit, beta Isozyme (PPP2CA)
Clone
2G2-H6-G11-E8
Host Species
Mouse
Reactive Species
human
Isotype
IgG2a
Format
affinity purified
Size
100 μL
Concentration
n/a
Applications
Western Blotting (WB),Immunoprecipitation (IP)
Reviews / Ratings
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Description
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases,and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme,which is composed of a catalytic subunit and a constant regulatory subunit,that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq,Mar 2010]PP2A can modulate the activity of phosphorylase B kinase casein kinase 2,mitogen-stimulated S6 kinase,and MAP-2 kinase. Subunit structure: Found in a complex with at least ARL2,PPP2CB,PPP2R1A,PPP2R2A,PPP2R5E and TBCD. Interacts with TBCD by similarity. PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families),the 48 kDa variable regulatory subunit,viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1,most probably through regulatory B56 subunits. Interacts with CTTNBP2NL. Subcellular location: Cytoplasm. Nucleus. Chromosome ? centromere. Cytoplasm ? cytoskeleton ? spindle pole. Note: In prometaphase cells,but not in anaphase cells, localizes at centromeres. During mitosis,also found at spindle poles. Sequence similarities: Belongs to the PPP phosphatase family. PP-1 subfamily.
Immunogen
Purified recombinant human full length PP2A beta protein expressed in E.coli